IV Solution Production has a high sterilization requirement. The BFS filling machine should be placed in at least C Grade Cleanroom and a Grade A air shower. PP material are generally used to endorse the high temperature sterilization step in the Sterilizing Autoclave. VSUN takes extra care and effort starting form building purification workshop to deliver an ensured sterile process for IV production.
For eyedrop production, the BFS filling machine should be place in at least C Grade Cleanroom with Grade A air shower. PE material are generally used for more flexible squeeze. Since PE material is not suitable for high temperature sterilization, the SIP (sterilize in place) is essential. Specific sterilizing requirement applies in different guidelines. According to CGMP, 121 0C purified steam run through all the pipelines for at least 30 minutes without any temperature drops.
Most of the solution for cosmetic products and inhaler are Suspension liquid. There is an additional mixer placed before filling step in our BFS system for uniformed filling in each bottle. Unlike other process, the liquid bypass the filter before filling step to prevent any quality change. Both suspension liquid filling and non-suspension liquid filling can be done on the same machine. Different kind of sterilization methods are applied for each product.
Most of the food supplement production dose have a strict rule for sterileness like pharmaceutical product. The BFS filling machine should be set in a clean room following production SOPs. Since final sterilization step is not required, PE material is often used as packaging for easier opening. There is a minimum amount of preservatives thanks to the limited contamination and human interference using BFS technology.